Physician Profile

Daniel B. Mark, MD

Education:
Medical School:
Tufts University School of Medicine, Massachusetts, MD, 1978

Residency:
University of Virginia Hospital, Virginia, Internal Medicine, 1980-1982

Fellowship:
Duke University Medical Center, North Carolina, Cardiology, 1982-1985

Harvard School of Public Health, Massachusetts, MPH, 1979

Clinical Interests:
Intensive cardiac care, patients with acute myocardial infarction and unstable angina, consultative cardiology

Research Interests:
Dr. Mark is a Professor of Medicine at the Duke University Medical Center and is the Director of the Outcomes Research and Assessment Group in the Duke Clinical Research Institute. The Outcomes group consists of 60 faculty and staff including physicians, economists, statisticians, and health policy researchers.

Dr. Mark's major research interests include medical economics and quality of life outcomes, outcomes research, and quality of medical care. Recent research projects directed by Dr. Mark include a 4,000-patient multi-dimensional technology assessment of coronary angioplasty (AHCPR); a 3,000-patient study of psychosocial prognostic factors in coronary disease (NHLBI); economic substudies in the ESSENCE (low molecular weight heparin in acute ischemic syndromes), EPISTENT (abciximab versus stents for percutaneous revascularization), and PURSUIT (eptifibatide in acute coronary syndrome patients) multi-center randomized trials; and a 3,000-patient substudy of economics and quality of life in the GUSTO megatrial (streptokinase versus t-PA). The latter investigation led to a cost-effectiveness analysis of t-PA and an international comparison of resource use and quality of life outcomes in Canadian and US patients in the year following myocardial infarction (both published in The New England Journal of Medicine).

Currently, Dr. Mark is directing a number of cost-effectiveness analyses for ongoing clinical trials including OAT (percutaneous revascularization versus medical therapy for occluded infarct arteries, NIH), STICH (surgical treatment for ischemic heart failure, NIH), and ADEPT (rate adaptive pacemaker therapy, NIH). He is the principal author of the AHCPR Unstable Angina Guidelines and a co-author of both the American College of Cardiology Guideline on Exercise Testing and their Coronary Stent Consensus Guideline. He is also the Editor of the American Heart Journal. Dr. Mark has published over 150 peer-reviewed articles, two books, and over 60 book chapters. He lectures widely in the US, as well as in Canada, South America, and Europe. Keywords: cost-effectiveness analysis, disease management, quality of life assessment, resource use.